49ers vs Colts
Upcoming Game
Tuesday, December 23, 2025
1:15 AM
Lucas Oil Stadium, Indianapolis, IN
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Betting Odds
Line: SF -1
O/U: 46.8
Head-to-Head Record (All Time)
IND
Colts
6
Wins
0
Ties
SF
49ers
4
Wins
Average Scores
49ers vs Colts
Colts
23.7 PPG
49ers
22.1 PPG
Home Field Advantage
49ers vs Colts
Colts at Home
3-2
60% Win Rate
49ers at Home
2-3
40% Win Rate
Highest Scoring Game
49ers vs Colts
65 Total Points
Oct 18, 1998
Colts 31 - 34 49ers
Last Meeting
49ers vs Colts
Oct 24, 2021
Colts 30 - 18 49ers
Colts Won
Recent Meetings (Last 5)
Oct 24, 2021
IND W
Colts 30
@
49ers 18
Oct 24, 2021
Colts 30
@
49ers 18
IND W
Oct 08, 2017
IND W
Colts 26
@
49ers 23
Oct 08, 2017
Colts 26
@
49ers 23
IND W
Sep 22, 2013
IND W
Colts 27
@
49ers 7
Sep 22, 2013
Colts 27
@
49ers 7
IND W
Nov 01, 2009
IND W
Colts 18
@
49ers 14
Nov 01, 2009
Colts 18
@
49ers 14
IND W
Oct 09, 2005
IND W
Colts 28
@
49ers 3
Oct 09, 2005
Colts 28
@
49ers 3
IND W