Bills vs Saints
Upcoming Game
Sunday, September 28, 2025
5:00 PM
Highmark Stadium, Orchard Park, NY
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Betting Odds
Line: BUF -12.7
O/U: 46.8
Head-to-Head Record (All Time)
NO
Saints
7
Wins
0
Ties
BUF
Bills
5
Wins
Average Scores
Bills vs Saints
Saints
24.1 PPG
Bills
18.7 PPG
Home Field Advantage
Bills vs Saints
Saints at Home
3-4
43% Win Rate
Bills at Home
1-4
20% Win Rate
Highest Scoring Game
Bills vs Saints
78 Total Points
Dec 27, 1998
Saints 33 - 45 Bills
Last Meeting
Bills vs Saints
Nov 25, 2021
Bills 31 - 6 Saints
Bills Won
Recent Meetings (Last 5)
Nov 25, 2021
BUF W
Saints 6
@
Bills 31
Nov 25, 2021
Saints 6
@
Bills 31
BUF W
Nov 12, 2017
NO W
Saints 47
@
Bills 10
Nov 12, 2017
Saints 47
@
Bills 10
NO W
Oct 27, 2013
NO W
Saints 35
@
Bills 17
Oct 27, 2013
Saints 35
@
Bills 17
NO W
Sep 27, 2009
NO W
Saints 27
@
Bills 7
Sep 27, 2009
Saints 27
@
Bills 7
NO W
Oct 02, 2005
NO W
Saints 19
@
Bills 7
Oct 02, 2005
Saints 19
@
Bills 7
NO W