Bills vs Panthers
Upcoming Game
Sunday, October 26, 2025
5:00 PM
Bank of America Stadium, Charlotte, NC
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Betting Odds
Line: BUF -5
O/U: 47.8
Head-to-Head Record (All Time)
CAR
Panthers
2
Wins
0
Ties
BUF
Bills
6
Wins
Average Scores
Bills vs Panthers
Panthers
14.4 PPG
Bills
21.6 PPG
Home Field Advantage
Bills vs Panthers
Panthers at Home
1-2
33% Win Rate
Bills at Home
4-1
80% Win Rate
Highest Scoring Game
Bills vs Panthers
49 Total Points
Dec 09, 2001
Panthers 24 - 25 Bills
Last Meeting
Bills vs Panthers
Dec 19, 2021
Panthers 14 - 31 Bills
Bills Won
Recent Meetings (Last 5)
Dec 19, 2021
BUF W
Panthers 14
@
Bills 31
Dec 19, 2021
Panthers 14
@
Bills 31
BUF W
Sep 17, 2017
CAR W
Panthers 9
@
Bills 3
Sep 17, 2017
Panthers 9
@
Bills 3
CAR W
Sep 15, 2013
BUF W
Panthers 23
@
Bills 24
Sep 15, 2013
Panthers 23
@
Bills 24
BUF W
Oct 25, 2009
BUF W
Panthers 9
@
Bills 20
Oct 25, 2009
Panthers 9
@
Bills 20
BUF W
Nov 27, 2005
CAR W
Panthers 13
@
Bills 9
Nov 27, 2005
Panthers 13
@
Bills 9
CAR W