49ers vs Panthers
Upcoming Game
VS
Tuesday, November 25, 2025
1:15 AM
Levi's Stadium, Santa Clara, CA
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Betting Odds
Line: SF -5
O/U: 46.8
Head-to-Head Record (All Time)
CAR
Panthers
13
Wins
0
Ties
SF
49ers
9
Wins
Average Scores
49ers vs Panthers
Panthers
24.8 PPG
49ers
23.4 PPG
Home Field Advantage
49ers vs Panthers
Panthers at Home
6-5
55% Win Rate
49ers at Home
4-7
36% Win Rate
Highest Scoring Game
49ers vs Panthers
73 Total Points
Sep 18, 2016
Panthers 46 - 27 49ers
Last Meeting
49ers vs Panthers
Oct 09, 2022
49ers 37 - 15 Panthers
49ers Won
Recent Meetings (Last 5)
Oct 09, 2022
SF W
Panthers 15
@
49ers 37
Oct 09, 2022
Panthers 15
@
49ers 37
SF W
Oct 27, 2019
SF W
Panthers 13
@
49ers 51
Oct 27, 2019
Panthers 13
@
49ers 51
SF W
Sep 10, 2017
CAR W
Panthers 23
@
49ers 3
Sep 10, 2017
Panthers 23
@
49ers 3
CAR W
Sep 18, 2016
CAR W
Panthers 46
@
49ers 27
Sep 18, 2016
Panthers 46
@
49ers 27
CAR W
Nov 10, 2013
CAR W
Panthers 10
@
49ers 9
Nov 10, 2013
Panthers 10
@
49ers 9
CAR W