49ers vs Cardinals
Upcoming Game
VS
Sunday, September 21, 2025
8:25 PM
Levi's Stadium, Santa Clara, CA
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Betting Odds
Line: SF -3.7
O/U: 47.8
Future Matchups
Nov 16, 2025
•
49ers @ Cardinals
9:05 PM
Head-to-Head Record (All Time)
ARI
Cardinals
22
Wins
0
Ties
SF
49ers
26
Wins
Average Scores
49ers vs Cardinals
Cardinals
21 PPG
49ers
23.8 PPG
Home Field Advantage
49ers vs Cardinals
Cardinals at Home
12-12
50% Win Rate
49ers at Home
14-10
58% Win Rate
Highest Scoring Game
49ers vs Cardinals
74 Total Points
Dec 17, 2023
Cardinals 29 - 45 49ers
Last Meeting
49ers vs Cardinals
Jan 05, 2025
49ers 24 - 47 Cardinals
Cardinals Won
Recent Meetings (Last 5)
Jan 05, 2025
ARI W
Cardinals 47
@
49ers 24
Jan 05, 2025
Cardinals 47
@
49ers 24
ARI W
Oct 06, 2024
ARI W
Cardinals 24
@
49ers 23
Oct 06, 2024
Cardinals 24
@
49ers 23
ARI W
Dec 17, 2023
SF W
Cardinals 29
@
49ers 45
Dec 17, 2023
Cardinals 29
@
49ers 45
SF W
Oct 01, 2023
SF W
Cardinals 16
@
49ers 35
Oct 01, 2023
Cardinals 16
@
49ers 35
SF W
Jan 08, 2023
SF W
Cardinals 13
@
49ers 38
Jan 08, 2023
Cardinals 13
@
49ers 38
SF W