49ers vs Cardinals
Upcoming Game
VS
Sunday, November 16, 2025
9:05 PM ET
State Farm Stadium, Glendale, AZ
Gridiron Duels Prediction
- Point Spread
- 49ers -3 to -8
- Moneyline
- 49ers -300 to -120
- Total (O/U)
- 41 to 48
Editorial ranges from Gridiron Duels. Not sportsbook odds.
Gridiron Duels Prediction
Point Spread
49ers -3 to -8
Moneyline
49ers -300 to -120
Total (O/U)
41 to 48
Editorial ranges from Gridiron Duels. Not sportsbook odds.
Get Tickets
Betting Odds
Line: SF -1.7
O/U: 47.8
Matchup Preview
Updated 1 month ago
Recent meetings favor San Francisco, while Arizona still carries a respectable franchise pedigree under its longer history. Both teams show flat form over their last outings, so recent rhythm offers little separation or clarity. There is no clear home tilt and past meetings have been moderate scoring, without big swings. Early down execution and red zone finishing will swing the outcome, and turnovers magnify mistakes. I give a slight lean to San Francisco given their deeper long term baseline and sustained excellence.
This view is based only on the categorical trends supplied and is not a substitute for official lines or detailed scouting.
Edge Meter
Offense
7/10
San Francisco's roster continuity and higher pedigree create a steadier offensive baseline.
Defense
7/10
Franchise depth and multi year consistency favor San Francisco on the defensive side.
Special Teams
5/10
No supplied trends point to a clear special teams advantage for either side.
Coaching
8/10
Sustained elite stretch and organizational stability tilt the coaching edge toward San Francisco.
Key Mismatches
-
Recent form versus franchise baselineBoth teams arrive in flat form, yet San Francisco's higher pedigree suggests a gap not reflected by recent trends.
-
Neutral venue impactHome edge is neutral so the venue should not decide this game despite usual home advantages.
-
Moderate scoring historyPast meetings point to a moderate scoring shape, so execution and turnovers will have outsized influence.
Trend Callouts
Both teams show flat recent form, so short term rhythm offers little separation
San Francisco has stronger franchise pedigree and sustained high level production
Head to head history suggests a moderate scoring game with no clear home tilt
Head-to-Head Record (All Time)
ARI
Cardinals
22
Wins
0
Ties
SF
49ers
26
Wins
Average Scores
49ers vs Cardinals
Cardinals
21 PPG
49ers
23.8 PPG
Home Field Advantage
49ers vs Cardinals
Cardinals at Home
12-12
50% Win Rate
49ers at Home
14-10
58% Win Rate
Highest Scoring Game
49ers vs Cardinals
74 Total Points
Dec 17, 2023
Cardinals 29 - 45 49ers
Last Meeting
49ers vs Cardinals
Jan 05, 2025
49ers 24 - 47 Cardinals
Cardinals Won
Recent Meetings (Last 5)
Jan 05, 2025
ARI W
Cardinals 47
@
49ers 24
Jan 05, 2025
Cardinals 47
@
49ers 24
ARI W
Oct 06, 2024
ARI W
Cardinals 24
@
49ers 23
Oct 06, 2024
Cardinals 24
@
49ers 23
ARI W
Dec 17, 2023
SF W
Cardinals 29
@
49ers 45
Dec 17, 2023
Cardinals 29
@
49ers 45
SF W
Oct 01, 2023
SF W
Cardinals 16
@
49ers 35
Oct 01, 2023
Cardinals 16
@
49ers 35
SF W
Jan 08, 2023
SF W
Cardinals 13
@
49ers 38
Jan 08, 2023
Cardinals 13
@
49ers 38
SF W
Upcoming Games for Cardinals
Upcoming Games for 49ers
Historical Performance (All-Time Stats)
ARI
Cardinals
All-time performance
ALL-TIME WIN %
105 Seasons
41%
593-812-41
PLAYOFF SEASONS
105 total
12
11% of seasons
CHAMPIONSHIPS
Last: 1947
2
1925, 1947
RECENT FORM
Last 5 years
42%
35-49-0
SF
49ers
All-time performance
ALL-TIME WIN %
79 Seasons
54%
630-526-16
PLAYOFF SEASONS
79 total
30
38% of seasons
CHAMPIONSHIPS
Last: 1994
5
1981, 1984, 1988, 1989, 1994
RECENT FORM
Last 5 years
56%
47-37-0