49ers vs Bills

Head-to-Head Record

All Time
SF
49ers 6 Wins
0 Ties
BUF
Bills 8 Wins

Average Scores

49ers vs Bills (All Time)

49ers 21.6 PPG
Bills 21.6 PPG

Home Field Advantage

49ers vs Bills (All Time)

49ers at Home 4-4
50% Win Rate
Bills at Home 4-2
67% Win Rate

Highest Scoring Game

49ers vs Bills

65 Total Points
Sep 13, 1992
49ers 31 - 34 Bills

Last Meeting

49ers vs Bills

Dec 01, 2024
49ers 10 - 35 Bills
Bills Won

Rivalry Facts

These teams have played 14 times, first meeting in 1972.

The Bills lead the all-time series 6-8.

The home team has won 57% of games in this matchup.

The Bills have won the last 3 meetings.

The last time 49ers won at Bills was Nov 30, 2008.

Largest victory: 42 points (49ers on Oct 7, 2012)

Current Form (Last 10)

SF
49ers
6-3 W6
Recent: W W W W L W L W L ← Latest
BUF
Bills
7-3 W7
Recent: W W W W L W L W W L ← Latest

Recent Meetings (Last 5)

Dec 01, 2024
BUF W
49ers 10
@
Bills 35
Dec 07, 2020
BUF W
49ers 24
@
Bills 34
Oct 16, 2016
BUF W
49ers 16
@
Bills 45
Oct 07, 2012
SF W
49ers 45
@
Bills 3
Nov 30, 2008
SF W
49ers 10
@
Bills 3

Upcoming Games for 49ers

Dec 29, 2025
vs Bears
Levi's Stadium, Santa Clara, CA
get tickets
Jan 04, 2026
vs Seahawks
Levi's Stadium, Santa Clara, CA
get tickets
View 49ers Team Page

Upcoming Games for Bills

Dec 28, 2025
vs Eagles
Highmark Stadium, Orchard Park, NY
get tickets
Jan 04, 2026
vs Jets
Highmark Stadium, Orchard Park, NY
get tickets
View Bills Team Page

Historical Performance (All-Time Stats)

SF

49ers

All-time performance
ALL-TIME WIN % 79 Seasons
54%
630-526-16
PLAYOFF SEASONS 79 total
30
38% of seasons
CHAMPIONSHIPS Last: 1994
5
1981, 1984, 1988, 1989, 1994
RECENT FORM Last 5 years
56%
47-37-0
BUF

Bills

All-time performance
ALL-TIME WIN % 65 Seasons
49%
486-505-8
PLAYOFF SEASONS 65 total
24
37% of seasons
CHAMPIONSHIPS Last: 1965
2
1964, 1965
RECENT FORM Last 5 years
74%
61-22-0

Top Seasons by Wins

All-Time Records
SF
49ers
Top 5 seasons
 Team page →
#1
1984
Won Super Bowl
15-1-0
93.8%
#2
1989
Won Super Bowl
14-2-0
87.5%
#3
1990
Lost Conference Championship
14-2-0
87.5%
#4
1992
Lost Conference Championship
14-2-0
87.5%
#5
1981
Won Super Bowl
13-3-0
81.3%
BUF
Bills
Top 5 seasons
 Team page →
#1
1990
Lost Super Bowl
13-3-0
81.3%
#2
1991
Lost Super Bowl
13-3-0
81.3%
#3
2020
Lost Conference Championship
13-3-0
81.3%
#4
2022
Lost Divisional Round
13-3-0
81.3%
#5
2024
Lost Conference Championship
13-4-0
76.5%

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