49ers vs Bills

There are no upcoming games scheduled for this matchup.

Head-to-Head Record (All Time)

SF
49ers
6
Wins
0
Ties
BUF
Bills
8
Wins

Average Scores

49ers vs Bills

49ers 21.6 PPG
Bills 21.6 PPG

Home Field Advantage

49ers vs Bills

49ers at Home 4-4
50% Win Rate
Bills at Home 4-2
67% Win Rate

Highest Scoring Game

49ers vs Bills

65 Total Points
Sep 13, 1992
49ers 31 - 34 Bills

Last Meeting

49ers vs Bills

Dec 01, 2024
49ers 10 - 35 Bills
Bills Won

Recent Meetings (Last 5)

Dec 01, 2024
BUF W
49ers 10
@
Bills 35
Dec 07, 2020
BUF W
49ers 24
@
Bills 34
Oct 16, 2016
BUF W
49ers 16
@
Bills 45
Oct 07, 2012
SF W
49ers 45
@
Bills 3
Nov 30, 2008
SF W
49ers 10
@
Bills 3

Upcoming Games for 49ers

Sep 21, 2025
vs Cardinals
Levi's Stadium, Santa Clara, CA
get tickets
Sep 28, 2025
vs Jaguars
Levi's Stadium, Santa Clara, CA
get tickets
Oct 03, 2025
@ Rams
SoFi Stadium, Inglewood, CA
get tickets
View 49ers Team Page

Upcoming Games for Bills

Sep 28, 2025
vs Saints
Highmark Stadium, Orchard Park, NY
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Oct 06, 2025
vs Patriots
Highmark Stadium, Orchard Park, NY
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Oct 13, 2025
@ Falcons
Mercedes-Benz Stadium, Atlanta, GA
get tickets
View Bills Team Page

Historical Performance (All-Time Stats)

SF

49ers

All-time performance

ALL-TIME WIN % 79 Seasons
54%
630-526-16
PLAYOFF SEASONS 79 total
30
38% of seasons
CHAMPIONSHIPS Last: 1994
5
1981, 1984, 1988, 1989, 1994
RECENT FORM Last 5 years
56%
47-37-0
BUF

Bills

All-time performance

ALL-TIME WIN % 65 Seasons
49%
486-505-8
PLAYOFF SEASONS 65 total
24
37% of seasons
CHAMPIONSHIPS Last: 1965
2
1964, 1965
RECENT FORM Last 5 years
74%
61-22-0